FOX04-DRI 10mg (Proxofim)

Name: FOX04-DRI 10mg (Proxofim)
SKU: 382
Availability: InStock

$300.00

FOXO4-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. This interference prevents FOXO4 from binding to the p53 protein, a key regulator that normally keeps damaged senescent cells alive. By disrupting this interaction, FOXO4-DRI enables those dysfunctional cells to undergo apoptosis—effectively clearing them from tissues. Research has shown that removing senescent “zombie” cells can restore tissue function, reduce inflammation, and improve organ health. Studies in animal models indicate that FOXO4-DRI supports cellular rejuvenation, enhances vitality, and may reverse biological signs of aging. Its mechanism also influences oxidative stress, insulin sensitivity, and cell cycle regulation, making it a promising senolytic compound in longevity and regenerative medicine research.

Category: Peptides

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FOXO4-DRI 10mg (Proxofim) – Advanced Peptide for Senescence Research

FOXO4-DRI 10mg (Proxofim) is a high-purity peptide developed for laboratory and research use, particularly in studies focused on cellular senescence, aging mechanisms, and tissue health. Known in scientific literature as a FOXO4–p53 interfering peptide, FOXO4-DRI has attracted attention for its role in exploring how senescent (“aging”) cells behave and how they might be selectively targeted.

🔬 What Is FOXO4-DRI (Proxofim)?

FOXO4-DRI is a synthetically engineered peptide design to disrupt the interaction between FOXO4 and p53 proteins—a pathway associated with the survival of senescent cells. In research models, this interaction helps scientists study how aged or damage cells persist and how they may be remove.

👉 Proxofim is a trade name sometimes use for formulations of FOXO4-DRI in research contexts.

⚙️ Key Research Focus Areas

🧪 Cellular Senescence Studies
Used to investigate how senescent cells accumulate and influence aging processes.
🧬 FOXO4–p53 Pathway Modulation
Explores mechanisms that regulate cell survival and programmed cell death.
🔄 Tissue Function & Regeneration Research
Supports studies on how clearing senescent cells may affect tissue environments.
⏳ Longevity & Aging Research
Widely examined in preclinical models for its role in age-related cellular dynamics.

🧠 How FOXO4-DRI Works (Research Overview)

FOXO4-DRI is design to:

Interfere with FOXO4’s binding to p53
Promote apoptosis (programmed cell death) in senescent cells in experimental settings
Help researchers study selective removal of dysfunctional cells

This mechanism makes it a valuable compound in senolytic research frameworks.